Alzheimer's Disease

The Biogen-developed treatment, called lecanemab, appears to have a more clear-cut effect on slowing the disease than the company’s previous Alzheimer’s drug, Aduhelm.

Alysson R. Muotri discusses his launch of brain organoids into outer space and how microgravity enriches our understanding of brain development and disease.

Research traces the evolution of a gene variant that reduces the risk of Alzheimer’s disease, finding that it originally evolved in response to infectious bacteria.

Maligned peptides such as the Alzheimer’s-associated amyloid precursor protein may have critical roles in the healthy brain.

The normal functions of peptides that aggregate in Alzheimer’s, Parkinson’s, and Huntington’s have been largely overlooked by scientists, but some argue that they are critical for understanding the development of disease.

Robin Ketteler and Hélène Plun-Favreau discuss the importance of autophagy and mitophagy regulation in neurodegenerative diseases.

Alysson Muotri shares how tapping into his inner creative spark fuels his pursuit of science.

How somatic mutations cause brain diseases

Researchers report molecular evidence of traumatic brain injury in headbutting animals, but other experts aren’t convinced.

Spatial and single cell analyses offer clues to Alzheimer’s disease progression.

Observational evidence for the connection is solidifying, and some clues are emerging about the mechanisms that may explain it.

Niacin, a form of vitamin B3 used to treat cardiovascular disease, helps immune cells in the brain fight neurodegenerative diseases such as Alzheimer’s in mice models, according to recent studies. Researchers hope that human clinical trials will swiftly follow.

A new study reveals a network of neurons that, when disrupted, impairs adaptation to new circumstances in several types of dementia.

Advancements in cryo-EM technology allow researchers to develop drugs and diagnostic tools for neurodegenerative diseases.

A study that transfused plasma from active to inactive mice suggests the protein clusterin enhances cognition.

A sensitive, automated immunoassay measures neurofilament light from patient blood samples.

The Northwestern University researcher studies how adaptive immune cells influence neurodegenerative disease.

The long noncoding RNA MINCR, implicated in ALS and Alzheimer’s disease as well as several types of cancer, appears to function differently when present at high versus low levels.

Experts discuss how untargeted metabolomic studies connect environmental factors with human disease.

Researchers say they hope to launch a clinical trial to test bumetanide, a diuretic approved in 2002, but how it might improve neural functioning is unclear.