Binding affinity

As a graduate student, Tharin Blumenschein learned that too much sodium hydroxide breaks down more than just bacterial cells.

Researchers require an accurate and high throughput method to evaluate proteolysis targeting chimera (PROTAC) interactions. 

Researchers assessed the binding affinities of PROTAC binary and ternary complexes with Spectral Shift technology.

Scientists used Spectral Shift assays to assess binding affinity and degradation of the oncogene regulator WDR5.

A combinatorial approach enabled high-throughput screening of protein libraries for desired target binding.

Translational scientists employ surface plasmon resonance (SPR) to make informed decisions when choosing their lead antibody candidates. 

Researchers use label-free surface plasmon resonance to measure affinity and binding kinetics in real time. 

In this webinar, Tim Heiseler will discuss the importance of assay design when measuring binding kinetics and affinity values, as well as strategies to mitigate avidity effects.

Renewed interest from the biotech industry sparks hope for drugging the nucleic acid to treat cancer and other conditions.

Computational tools take some of the cost—and guesswork—out of drug discovery.