cancer biology

This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.

Viscous solutions accelerate the migration of tumor cells and may enable metastasis, according to a new study.

Human and mouse oral tumors recruit nerves to produce peptides that the cancer cells need to survive—but this process can be blocked with a migraine drug.

A study finds that XIST, the gene that shuts down one X chromosome in people who have two, is linked to cancer in males. 

Most differences in gene expression among cells within a tumor are likely due to environment or noise, a study suggests. 

Whether the finding of a novel mechanism for cancer-related pain can lead to better treatments for neuropathic pain in people remains to be seen.

An in situ map of copy number variations in prostate tissue reveals that purportedly cancerous genomic changes frequently occur in the healthy tissue surrounding tumors.

Disturbing circadian rhythms in organoids and mice increases intestinal tumor growth, findings that may explain a recent rise in colon cancer among young adults, the researchers behind the work say.

More cancer cells are shed from primary tumors when individuals are asleep than when they’re awake, according to observations in mouse models and a small cohort of breast cancer patients.

A study reveals a molecular pathway linking exercise to an amped-up immune response to pancreatic cancer and greater responsiveness to treatment.

A technique for quantifying tumor mRNA production from messy tissue sample data uncovers an unexpected correlation between it and disease stage in 15 cancer types.

Analyzing the whole genome sequences of more than 18,000 tumors, researchers catalog nearly 60 new patterns of mutations that could inform cancer treatment.

In vitro and mouse experiments show how cancer cells forced through tiny pores—mimicking the physical experience of metastasis—resisted programmed cell death and avoided detection by the immune cells that would normally kill them.

Observational evidence for the connection is solidifying, and some clues are emerging about the mechanisms that may explain it.

New research in mice reveals why natural killer cells, normally effective at hunting cancer, are sometimes stopped in their tracks.  

Unsatisfied by how treatments for childhood leukemia failed to prevent the disease’s return, Pinkel combined them all—and virtually cured the disease.

A growing appreciation of the bacterial assemblages that live within tumors has researchers striving to understand and capitalize on their role.

From diagnosis to tracking treatment responses, bacteria and other microbes in the blood, gut, and tumors of cancer patients may provide helpful hints for improving their care.

A study uncovers a novel connection between the biomolecule and cancer progression.

When coated with positively charged particles, the bacteria shuttled antigens out of tumors and activated the immune system, a study finds.