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A DNA sequence represented by its base letters.
Measuring the Genome and Methylome at Single Base Resolution
Researchers can build models to predict gene expression by detecting and differentiating between cytosine methylation and hydroxymethylation marks in the genome.
Measuring the Genome and Methylome at Single Base Resolution
Measuring the Genome and Methylome at Single Base Resolution

Researchers can build models to predict gene expression by detecting and differentiating between cytosine methylation and hydroxymethylation marks in the genome.

Researchers can build models to predict gene expression by detecting and differentiating between cytosine methylation and hydroxymethylation marks in the genome.

DNA sequencing

Graphic of three double-stranded DNA helices with bases colored yellow, light green, blue, and dark blue
ABC Sequencing Helps Scientists Get Back to Basics
Element Biosciences | Feb 16, 2024 | 1 min read
A novel instrument simplifies and optimizes every sequencing step.
A drawing of the sun on the sand, surrounded by items that people use to protect themselves from UV damage, including sunscreen, a hat, and sunglasses.
Taking Snapshots of DNA Damage in Skin Cancer
Deanna MacNeil, PhD | Aug 15, 2023 | 3 min read
Researchers turn to high resolution sequencing to explain recurrent melanoma mutations caused by UV exposure.
Abstract blue brain image
Integrating Technologies into Neurodegenerative Disease Research
Thermo Fisher Scientific | Jun 6, 2023 | 1 min read
Genetic analysis techniques give researchers the power to better understand, detect, and treat disease.
Artistic rendition of droplet DNA amplification
Finally, Scientists Sequence Single Cells with Long-Read Technology
Holly Barker, PhD | Mar 8, 2023 | 4 min read
By combining two innovative approaches, researchers can now sequence the full spectrum of mutational differences between individual cells’ genomes.
Microscopy view of cancerous human cervix cells stained violet.
Why Some HPV Infections Carry More Cervical Cancer Risk
Dan Robitzski | Feb 2, 2023 | 5 min read
Where and how human papillomavirus integrates itself into the human genome steers the infection’s clinical outcomes, finds a large, multifaceted study.
Better Ways to Extract DNA
Better Ways to Extract DNA
The Scientist | Jan 17, 2023 | 1 min read
Learn how to obtain high throughput DNA purification that improves next-generation sequencing.
A fishing cat with a fish in its mouth
Genome Spotlight: Fishing cat (Prionailurus viverrinus)
Christie Wilcox, PhD | Dec 22, 2022 | 5 min read
A high-quality reference genome for this vulnerable feline may help scientists understand why they’re so prone to transitional cell carcinoma in captivity.
2022 Top 10 Innovations 
2022 Top 10 Innovations
The Scientist | Dec 12, 2022 | 10+ min read
This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.
Pink- and purple-stained cells clustered into glands
Phenotypic Variation in Cancer Cells Often Not Due to Mutations
Jef Akst | Oct 26, 2022 | 3 min read
Most differences in gene expression among cells within a tumor are likely due to environment or noise, a study suggests. 
How robotics and automation provide a streamlined, consistent, and precise solution.
Automated Pipetting for Effortless DNA Library Normalization 
INTEGRA BIOSCIENCE | Oct 14, 2022 | 1 min read
How robotics and automation provide a streamlined, consistent, and precise solution.
Illustration showing assembly Versus Alignment
Infographic: The Sequencing and Assembly of the Human Genome
Brianna Chrisman and Jordan Eizenga | Sep 1, 2022 | 5 min read
With ever-advancing genetic technologies, researchers continue to document the genetic code of the human species.
Illustration showing a puzzle piece of DNA being removed
Large Scientific Collaborations Aim to Complete Human Genome
Brianna Chrisman and Jordan Eizenga | Sep 1, 2022 | 10+ min read
Thirty years out from the start of the Human Genome Project, researchers have finally finished sequencing the full 3 billion bases of a person’s genetic code. But even a complete reference genome has its shortcomings.
Illustration of a DNA virus sneaking genetic material into a host’s nucleus
Infographic: Possible Mechanisms of Gene Transfer in Eukaryotes
Christie Wilcox, PhD | Jul 5, 2022 | 6 min read
Genetic studies have made it clear that eukaryotic horizontal gene transfer can and does happen. Exactly how, though, remains speculative.
Landscape illustration
Horizontal Gene Transfer Happens More Often Than Anyone Thought
Christie Wilcox, PhD | Jul 5, 2022 | 10+ min read
DNA passed to and from all kinds of organisms, even across kingdoms, has helped shape the tree of life, to a large and undisputed degree in microbes and also unexpectedly in multicellular fungi, plants, and animals.
Illustration of light blue speckled DNA helix on a dark background
Study Nearly Doubles Known Cancer-Linked Mutational Signatures
Jef Akst | Apr 22, 2022 | 2 min read
Analyzing the whole genome sequences of more than 18,000 tumors, researchers catalog nearly 60 new patterns of mutations that could inform cancer treatment.
Blue-toned illustration of the DNA double helix, with additional DNA strands in the background
Nearly Complete Human Genome Sequenced
Jef Akst | Jun 8, 2021 | 2 min read
In a preprint, researchers fill in some of the holes left in the first draft of the human genetic code, published at the turn of the century.
Q&A: George Church’s Genome Up for Auction
Jef Akst | Apr 19, 2021 | 5 min read
A founder of the field of synthetic biology is selling data from his own DNA as a nonfungible token, or NFT, through Nebula Genomics, a personal genome company he cofounded.
Scaling BAC on Time and Sample
The Scientist Creative Services Team in collaboration with Agilent Technologies | Apr 9, 2021 | 3 min read
A new and simplified quality control method confirms the cloning of both small and large inserts in bacterial artificial chromosomes (BACs) with significantly less time and sample.
The Scientist Speaks Ep. 16 - At the Breaking Point: Mitochondrial Deletions and the Brain
The Scientist | Mar 31, 2021 | 1 min read
Researchers characterize large mitochondrial deletions to understand their implications in neurological disorders.
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