gene regulation

The discovery of an inducible switch in Escherichia coli that controlled lactose metabolism offered the first clues into gene expression.

Gene knockdown using RNAi enables gene function studies, with applications from pest control to biotherapeutics.

Victor Ambros and Gary Ruvkun won this year’s Physiology or Medicine award for the discovery of microRNA and its role in post-transcriptional gene regulation.

Enhancing protein diversity and guiding cellular functions, alternative splicing is a key dimension of genetic regulation.

Evgeny Kvon leverages transgenic models and genomic techniques to uncover the ways enhancers control the transcription of genes.

In this podcast series, scientists discuss the unique ways they employ synthesized DNA libraries in their research. 

A robust platform for analyzing 3D genome architecture and epigenomic features enables a deeper understanding of gene regulation in specific cell types.

E. coli divides faster than it can replicate its genome, while simultaneously expressing its genes. Scientists recently revealed the intricate molecular coordination that makes this possible.

In this webinar, learn about the origins of artificial gene circuits and how researchers currently use synthetic biology strategies to uncover new drugs. 

Scientists discuss their latest findings on immune cell dynamics, neurodegenerative disease risk factors, and rare cell types obtained from bulk and single cell RNA sequencing experiments.

The HIV protein Nef can cause long-term genetic changes that lead to hyperreactive immune cells, according to research in human cells and mice. 

Parents’ mutations, even if they’re not inherited by offspring, could affect subsequent generations through changes to epigenetic marks, a study finds.

A study finds that XIST, the gene that shuts down one X chromosome in people who have two, is linked to cancer in males. 

The molecular biologist studies how chemical modifications to RNA building blocks change the way RNA regulates complex cellular processes.

Discover how to best map a cell’s epigenetic landscape

An expert panel will discuss how a functional cell library confirms critical insights from previous omics studies. Additionally, they will introduce an innovative platform that connects single cell transcriptomics with functional proteomics for the first time.

The long noncoding RNA MINCR, implicated in ALS and Alzheimer’s disease as well as several types of cancer, appears to function differently when present at high versus low levels.

The dynamic behavior of a transcriptional activator can be used to specify the activity level of its target gene, a study suggests.

Genes associated with preterm birth and protecting the fetus from the mother’s immune system appear to be regulated by HAND2.