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A white mouse sits in a Petri dish against a blue background.
A Neural Thermostat Sets the Intensity of Immune Responses
Specialized neurons in the brainstem and vagus nerve provide potential therapeutic targets for treating inflammatory disorders.
A Neural Thermostat Sets the Intensity of Immune Responses
A Neural Thermostat Sets the Intensity of Immune Responses

Specialized neurons in the brainstem and vagus nerve provide potential therapeutic targets for treating inflammatory disorders.

Specialized neurons in the brainstem and vagus nerve provide potential therapeutic targets for treating inflammatory disorders.

inflammation

A human torso with the large bowel depicted in blue and the appendix in red.
Why Do Humans Have an Appendix?
Hannah Thomasy, PhD and Priyom Bose, PhD | Sep 2, 2024 | 2 min read
Long believed to be purely vestigial, this troublesome organ may play an important role in gut and immune function.
3D rendering of a transparent human torso to show the lungs and bronchiole structures in them.
Prenatal Inflammation Makes Mice Susceptible to Asthma
Shelby Bradford, PhD | Aug 20, 2024 | 4 min read
Maternal immune responses during mice gestation led to a hyperactive population of innate-like immune cells in offspring that contributed to altered lung composition and function.
A woman and a child sitting on a couch blowing their noses. 
A Better Mucus Model
Aparna Nathan, PhD | Aug 20, 2024 | 4 min read
A more realistic model of the mucus layer that lines the lungs and gut could provide important insights into the function of this critical defensive barrier.
The feet of several runners wearing brightly colored shoes.
How Exercise Sparks, then Soothes, Inflammation
Rachael Moeller Gorman | May 15, 2024 | 4 min read
Regulatory T cells in muscles surge after exercise, quelling inflammation, protecting mitochondria, and enhancing performance.
Abstract pill capsules in neon blue floating against a dark blue background
Supporting Drug Development with CyTOF Technology
Standard BioTools | Apr 18, 2024 | 1 min read
From basic research to efficacy testing, scientists use cytometry by time of flight (CyTOF) to analyze complex biological systems.
A whitish neutrophil with a red multi-lobed nucleus.
Cell Surface RNA Helps Neutrophils Get Around
Holly Barker, PhD | Apr 2, 2024 | 4 min read
A new study confirms reports of membrane-bound RNA molecules and points to their role in neutrophil migration.
TK
Bat Immune Systems: The Original Antivirus Programs
Hannah Thomasy, PhD | Mar 15, 2024 | 3 min read
Bats stay healthy while hosting some of the world’s deadliest viruses. Scientists are just beginning to understand how.
Naked mole rat
Fighting Cancer: Lessons from the Naked Mole-rat
Hannah Thomasy, PhD | Dec 1, 2023 | 2 min read
Mice live longer, healthier lives thanks to a gene from their glabrous subterranean cousins.
Aging and Cancer
Aging and Cancer
Rebecca Roberts, PhD | Nov 14, 2023 | 6 min read
The relationship between aging and cancer is complex, with several shared underlying mechanisms. 
Infographic showing how CITE-seq detects protein and gene expression in the same cell
Infographic: Capturing a More Complete Picture of Expression
Deanna MacNeil, PhD | Jun 1, 2023 | 1 min read
CITE-seq draws upon the unbiased nature of single-cell RNA sequencing to gather new insights about protein and gene expression within the same cell.
Illustration of a virus
Vaccines: Sex Matters
Niki Spahich, PhD | Jun 1, 2023 | 3 min read
Male patients who recover from mild COVID-19 have baseline immune states primed to mount stronger responses to future challenges than female patients.
3D image of a neuron cell network with a red glow representing inflammation.
New Insight into Brain Inflammation Inspires New Hope for Epilepsy Treatment 
Deanna MacNeil, PhD | Jun 1, 2023 | 2 min read
Clinicians and researchers teamed up to investigate how inappropriate proinflammatory mechanisms contribute to the pathogenesis of drug-refractory epilepsy.
Surface rendering of microscopy image showing two dendritic cells (green) communicating with a nociceptor neuron (violet).
How Cells in the Skin Team Up To Fight Pathogens
Rachael Moeller Gorman | Apr 12, 2023 | 4 min read
Immune cells and pain neurons form complex partnerships to protect our bodies from pathogens, new research reveals.
T regulatory cell in red sandwiching an antigen presenting cell in blue
Gut Bacteria Help T Cells Heal Muscle: Study
Natalia Mesa, PhD | Mar 14, 2023 | 4 min read
Regulatory T cells in the colon travel to muscles to promote wound healing in mice, raising questions about how antibiotics may impact injury recovery.
An artistic rendering of SARS-CoV-2 made to look like stained glass
SARS-CoV-2 Infection Can Alter Future Immune Reponses
Niki Spahich, PhD | Feb 22, 2023 | 3 min read
Males recovered from mild COVID-19 have baseline immune states primed to mount stronger responses to future challenges.
A 3D medical illustration of a human heart with a cardiogram in the foreground and a blue background that includes DNA helices.
Connecting the Complexities of Heart Failure and Aging
Deanna MacNeil, PhD | Feb 13, 2023 | 3 min read
Researchers learned how IGFBP7, a senescence signaling protein and biomarker, promotes cardiac remodeling and cellular aging.
Human brain stock photo
New Insight into Brain Inflammation Inspires New Hope for Epilepsy Treatment
Deanna MacNeil, PhD | Jan 23, 2023 | 3 min read
Clinicians and researchers teamed up to investigate how inappropriate proinflammatory mechanisms contribute to the pathogenesis of drug-refractory epilepsy.
A man working at a computer late at night
Shift Work Early in Life Results in Increased Stroke Severity in Middle Age
Jennifer Zieba, PhD | Jan 11, 2023 | 3 min read
Researchers found that shifted sleep/wake cycles in young rats result in increased functional deficits and mortality following stroke later in life.
Coronal section of a brain
Immunity-Linked Genes Expressed Differently in Brains of Autistic People
Laura Dattaro, Spectrum | Jan 11, 2023 | 4 min read
Data from postmortem brain tissues adds to the evidence that inflammation is associated with autism.
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