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Some pills strewn about next to an alarm clock on a blue background.
Why Timing Matters When Taking Medicines
Human liver cells follow their own circadian rhythms, which regulate drug metabolism and infection.
Why Timing Matters When Taking Medicines
Why Timing Matters When Taking Medicines

Human liver cells follow their own circadian rhythms, which regulate drug metabolism and infection.

Human liver cells follow their own circadian rhythms, which regulate drug metabolism and infection.

liver

On the left is a brain in blue connect by blue electricity-like lines to a heart in red on the right side of the image.
Can the Brain Help Heal a Broken Heart?
Hannah Thomasy, PhD | Aug 28, 2024 | 6 min read
Stimulation of neural reward pathways may help mice recover from heart attacks.
Microscopy image of hepatocytes stained in pink with purple nuclei.
Liver Proteins Keep T Cells Out of Tumors
Aparna Nathan, PhD | Jun 21, 2024 | 4 min read
A new study finds an unexpected role for hepatocytes in anticancer immunity.
Beyond Gravity: Immune-Mediated Liver Damage in Spaceflight
Beyond Gravity: Immune-Mediated Liver Damage in Spaceflight
The Scientist | Jul 27, 2023 | 1 min read
In this webinar, Noah Allen will explore how spaceflight changes the way organs and systems function, focusing on immune-mediated liver damage.
Mouse running on wheel
An Exercise-induced Liver Enzyme Boosts Metabolism
Natalia Mesa, PhD | Jul 7, 2023 | 3 min read
Exercise drives the liver to produce the CES2 enzyme, which circulates in blood and delivers some of the benefits of exercise in mice. 
The face of a young woman and the face of an old man surrounded by mechanical clocks.
Daily Gene Expression Rhythms Vary with Sex and Age: Study
Alejandra Manjarrez, PhD | Feb 2, 2023 | 3 min read
By studying tissues from deceased people, a team found that women have more rhythmical gene expression and that this molecular rhythmicity decreases with age.
A nine-banded armadillo walking on dry grass.
Leprosy Bacterium Rejuvenates Armadillos’ Livers
Alejandra Manjarrez, PhD | Nov 15, 2022 | 4 min read
Mycobacterium leprae appeared to reprogram the animals’ livers to a state partially resembling early development, resulting in healthy organ growth.
illustration of liver with veins in blue and arteries in red.
Ethanol-Making Microbe Tied to Nonalcoholic Fatty Liver Disease
Natalia Mesa, PhD | Oct 19, 2022 | 4 min read
A study adds to evidence linking gut bacteria to liver conditions in people who don’t drink excessive amounts of alcohol. 
Histology of mouse lungs using purple and green staining on a white background. Left: a healthy lung. Right: a fibrotic lung.<br><br>
Immunotherapy Treats Fibrosis in Mice
Alejandra Manjarrez, PhD | Sep 15, 2022 | 4 min read
Researchers report that vaccination against proteins found on profibrotic cells reduced liver and lung fibrosis in laboratory rodents.
fuorescence microscopy of kidney tissue
Artificial Blood Breathes New Life Into Dead Pigs’ Cells
Andy Carstens | Aug 3, 2022 | 2 min read
A study’s authors say their oxygenating cocktail may lead to technologies that preserve organs in deceased people for longer periods for transplantation.
Ribbon diagram of the protein coat of an adeno-associated virus
Preprints Propose Constellation of Causes for Kids’ Liver Disease
Christie Wilcox, PhD | Jul 25, 2022 | 2 min read
Two independent groups suggest the suite of recent unexplained hepatitis cases may stem from coinfection with an adeno-associated virus and a helper adeno- or herpesvirus, a duo which may be especially virulent in children with a particular genetic variant.
Liver glowing red underneath human torso
Mysterious Hepatitis Cases Reported in Young Children
Natalia Mesa, PhD | Apr 18, 2022 | 3 min read
Officials have ruled out known hepatitis viruses as the cause of a rash of illnesses in Europe and the US.
Select effective AAVs for gene therapy
A Model for Better Gene Therapy
PhoenixBio | Apr 5, 2022 | 1 min read
Explore how humanized liver chimeric mouse models smooth the transition between the laboratory and clinical trials.
mice on wheel and ground
Exercise-Associated Protein Boosts Brain Function in Mice
Chloe Tenn | Dec 9, 2021 | 5 min read
A study that transfused plasma from active to inactive mice suggests the protein clusterin enhances cognition.
Explore tissue-specific organoid protocols
Building Better Organoids
Bio-Techne | Aug 17, 2021 | 1 min read
Explore tissue-specific protocols for growing organoids from primary tissue or stem cells.
Conceptual illustration of cells releasing cytokines in various shades of blue
Spleen-to-Liver Signals Control Systemic Inflammation
Ruth Williams | Apr 29, 2021 | 3 min read
In rats, the spleen directs a cytokine surge that drives system-wide inflammation, but it is not, as once believed, the main producer of the chemical messenger.
Organoids Repair Bile Ducts
Abby Olena, PhD | Feb 18, 2021 | 4 min read
Researchers determined that when introduced into damaged mouse or donated human livers, these lab-grown tissues could integrate into bile ducts and function normally.
Stress-Induced Chromosome Changes Protect Flies’ Aging Brains
Lisa Winter | Dec 1, 2020 | 2 min read
Brain cells in older Drosophila tend to have more than two complete sets of chromosomes, and that polyploidy most likely has a protective function, a study shows.
Image of the Day: Red-Feathered Finches
Emily Makowski | Sep 30, 2019 | 1 min read
Scientists uncover a potential reason why redder house finches have better health.
Gut Microbe Linked to Nonalcoholic Fatty Liver Disease
Abby Olena, PhD | Sep 19, 2019 | 3 min read
Researchers find strains of the bacterium Klebsiella pneumoniae that produce high levels of alcohol in 60 percent of patients with the condition.
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