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mutational signature

Artist’s 3D rendering of malignant cancer cells, illustrated in pink, as it would appear under a scanning electron microscope.

Underdog Enzyme Likely Responsible for Mutations in Most Cancers

Sophie Fessl, PhD | Jul 28, 2022 | 3 min read

A previously overlooked enzyme called APOBEC3A is linked to the most prevalent mutational signatures in cancer cell lines, a study finds.

Genetic Mutations Can Be Benign or Cancerous—a New Method to Differentiate Between Them Could Lead to Better Treatments

Ryan Layer, The Conversation | May 27, 2022 | 5 min read

Tumors contain thousands of genetic changes, but only a few are actually cancer-causing. A quicker way to identify these driver mutations could lead to more targeted cancer treatments.

Illustration of light blue speckled DNA helix on a dark background

Study Nearly Doubles Known Cancer-Linked Mutational Signatures

Jef Akst | Apr 22, 2022 | 2 min read

Analyzing the whole genome sequences of more than 18,000 tumors, researchers catalog nearly 60 new patterns of mutations that could inform cancer treatment.