Human and mouse oral tumors recruit nerves to produce peptides that the cancer cells need to survive—but this process can be blocked with a migraine drug.
For the first time, a team visualizes sensory nerves projecting into adipose tissue in mice and finds these neuronal cells may counteract the local effects of the sympathetic nervous system.
The device can chill nerves as small as a few millimeters across, but more testing and modifications are necessary before it could relieve pain in humans.
In mice, a kind of immune memory appears to protect the cells against future harm, a finding that could provide insight into treatments for irritable bowel syndrome and other inflammatory digestive conditions.
Research in mice suggests that moderating nerve activity with drugs or electrical pulses could modify tissue immune responses, curtailing the chronic pain often associated with inflammatory conditions.
At $2 million for a single dose, Novartis’s Zolgensma is the most expensive medicine to date, but still less expensive over a lifetime than another approved drug for the rare genetic disease.
Researchers are using the tissue, synthesized with human pluripotent stem cells and implanted into mice, to study a rare form of Hirschprung’s disease.
A man whose hand and lower arm were amputated could sense shapes and stiffness and modulate the force of his grasp using a prosthetic hand that was temporarily wired to nerves in his upper arm.