neurodegeneration

Scientists advance Parkinson’s disease biomarker research one sniff at a time.

In this webinar, scientists will discuss the advantages of assembloid models and the fundamentals of imaging 3D neuronal architecture. 

After 20 years, scientists studying patients with cerebellar degeneration discovered a mutation that disrupts autophagy.

New sequencing technologies unmask a mutation that sheds new light on ataxia.

A new platform for screening astrocyte reactivity helps researchers uncover potential therapeutic interventions to treat neurodegenerative conditions.

Researchers redefine the lost art of smelling illness using one woman’s exquisitely sensitive nose.

Understanding the role of immune cells in neurodegeneration may help scientists develop new diagnostic, prognostic, and treatment tools.

Scientists discover how to convert the brain’s glial cells into multipotent neural stem cells.

Female postmortem brains contain more S-nitrosylated C3 proteins, likely linked to menopause, which instruct immune cells to kill neuronal synapses.

Neurons transmit sensory and mechanical information across synapses and along axons throughout the body via chemical signals and electrical impulses.

Dialing up the activity of a protein called SYK in the brain’s “janitors” could provide an avenue to treat Alzheimer’s and other neurodegenerative diseases.

Tricking the body into mimicking a fasting state may hold the key to fighting age-related cognitive decline. 

The APOE4 variant causes cholesterol buildup in the cells that make protective fatty sheaths for neurons, possibly helping explain its role in neurodegeneration.

Paul George shares how a dual career as a physician and scientist enriches his research.

Damaged lysosomes are repaired by a lipid-based signaling pathway dubbed PITT that could be targeted to treat neurodegenerative disease, its discoverers say.

The MIT biologist studies how RNA molecules self-assemble and the role these accumulations may play in diseases such as ALS and Huntington’s.

The Biogen-developed treatment, called lecanemab, appears to have a more clear-cut effect on slowing the disease than the company’s previous Alzheimer’s drug, Aduhelm.

Erdem Gültekin Tamgüney discusses the future of neurodegeneration research and his work exploring the link between stroke and Parkinson’s disease.

Mice with overactive LINE-1 retrotransposons in their brains exhibit movement difficulties, suggesting the genetic elements may play a role in ataxia in humans.