RNAi

Gene knockdown using RNAi enables gene function studies, with applications from pest control to biotherapeutics.

A quantitative immunofluorescence assay combines the best aspects of traditional Western blots and ELISAs.

The third FDA approval of an RNAi-based therapeutic marks the growing success of a technique that took two decades to get off the ground.

The genetically modified bacteria spark an RNAi response in the parasite that leads to self-destruction—and perhaps a path to combatting colony collapse disorder.

From the effects of political upheaval on research to claims of gene-edited babies, the year has been a tumultuous one for the scientific community.

Alnylam’s patisiran interferes with the production of a mutated protein present in people with hereditary transthyretin amyloidosis.

If approved, patisiran will be the first RNAi therapeutic on the market. 

Researchers engineer bacterial CRISPR-Cas13 to knock down RNA in mammalian cells.

Two freely available databases include data on hundreds of human cancer cell lines. 

A new study adds to the evidence that mammalian cells can use small interfering RNAs to defend against viruses, but questions remain about physiological importance.

This month, the EPA registered four products that include RNA interference technology intended to control corn rootworms. 

Our guide to all known forms of RNA, from cis-NAT to vault RNA and everything in between.

A recent CRISPR study contradicted years of RNA interference research on a well-studied cancer drug target. But is it the last nail in the coffin for RNAi as a screening tool? 

Plants and fungi can use conserved RNA interference machinery to regulate each other’s gene expression—and scientists think they can make use of this phenomenon to create a new generation of pesticides.

Successful late-stage clinical trials could mark the maturation of a new drug development platform, but the path to commercialization is not without hurdles.

A recent paper challenges earlier findings that germline factors expressed in normal body cells influence life span in C. elegans.

Lacing insect food with microbes encoding double-stranded RNAs can suppress insect gene expression.

Researchers mix bacteria genetically engineered to express double-stranded RNA into insect food.

Newer CRISPR tools for manipulating transcription will help unlock noncoding RNA’s many roles.