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Crystal structure of adeno-associated virus serotype 3B
A Deep Dive into Viral Vectors for Gene Therapy 
As the demand for viral vectors rises in new gene therapy approaches, scientists seek ways to optimize their production.
A Deep Dive into Viral Vectors for Gene Therapy 
A Deep Dive into Viral Vectors for Gene Therapy 

As the demand for viral vectors rises in new gene therapy approaches, scientists seek ways to optimize their production.

As the demand for viral vectors rises in new gene therapy approaches, scientists seek ways to optimize their production.

viral vectors

A man in a blue shirt holds a pinkish paper cut out of a pair of lungs.
Genetic Engineering Hides Donor Organs from Host Immune System
Hannah Thomasy, PhD | Sep 30, 2024 | 5 min read
Antigen knockdown prevented organ rejection in minipigs, even in the absence of immunosuppression.
An illustration of orange, blue, and grey lentiviral particles on a white background.
Scaling Up Lentiviral Vector Manufacturing 
Thermo Fisher Scientific | Sep 9, 2024 | 1 min read
Discover how innovative production and clarification products improve lentiviral vector generation.
An illustration of an adeno-associated virus.
Streamlining Viral Gene Therapy Development
The Scientist and Charles River Laboratories, Inc. | Aug 27, 2024 | 3 min read
Off-the-shelf and custom plasmid DNA and viral vector products help scientists take their gene therapy research to the next level.
Conceptual vector image of scientist engage in molecular biology research.
Helper Plasmids Lend a Hand to AAV Production
Sartorius and Polyplus | Aug 21, 2024 | 1 min read
An innovative helper plasmid improves adeno-associated virus quality and infectivity.
Discover What Digital PCR Can Do Across a Wide Range of Applications
Digital PCR Applications
Thermo Fisher Scientific | Jul 9, 2024 | 1 min read
Digital PCR is highly sensitive and precise, making it ideal for detecting rare targets and measuring small-fold changes.
Equally-sized droplets of a nucleic acid sample.
Digital PCR: The Journey to Superior Data 
Bio-Rad Laboratories | Aug 24, 2023 | 1 min read
With digital PCR (dPCR), researchers accurately and precisely quantitate nucleic acid samples.
MRI images of brains from patients with epilepsy
Defending against Dravet
Aparna Nathan, PhD | Aug 21, 2023 | 3 min read
Gene therapy may be the first step toward curing a rare genetic epilepsy.
White mouse at the edge of a desk
The Heart Can Directly Influence Our Emotions
Natalia Mesa, PhD | Mar 1, 2023 | 4 min read
Researchers find that an increased heart rate can induce anxiety in mice, given the right context.
Learn How Researchers Make the Most of Viral Vectors for Gene Therapy
Viral Vector Platforms for Gene Therapy
The Scientist | Feb 9, 2023 | 1 min read
In both the laboratory and clinic, scientists harness viral genetic transfer capabilities to develop gene therapies that modulate cellular function.
How to Produce Successful Viral Vectors 
How to Produce Successful Viral Vectors
The Scientist | Nov 23, 2022 | 1 min read
Learn how to be successful with transfection parameters, cell culture considerations, and assessment methodology when producing viral vectors.
Learn how researchers develop novel vaccines with new technologies 
The Vaccine Journey: From Bench to Needle
Bio-Rad | Nov 4, 2022 | 1 min read
Researchers build better vaccines thanks to innovative technology.
Learn about establishing a Gene Therapy Manufacturing Strategy 
Considerations for Gene Therapy Manufacturing Strategies
Thermo Fisher Scientific | Oct 24, 2022 | 1 min read
Discover tips for setting up and optimizing adeno-associated virus production.
To flag neurons that have experienced genotoxic stress, researchers developed an in vivo sensor using an adeno-associated viral vector, called PRISM. Because a cell’s DNA damage response (DDR)—which activates in response to stressors such as environmental toxins or the buildup of misfolded proteins—also responds to invading pathogens, PRISM has an easier time transfecting cells whose damage response mechanisms are preoccupied with existing DNA damage. Once inside, the virus hijacks the neuron’s DNA replication machinery, which reverts an engineered frameshift mutation in the virus and thereby prompts the production of a fluorescent protein that can be observed via microscopy.
Infographic: DNA Damage Viewed with Unprecedented Clarity
Amanda Heidt | Aug 15, 2022 | 2 min read
A new genetic sensor called PRISM makes use of a host cell’s DNA replication machinery to trigger fluorescence in neurons with damaged DNA.
Broken DNA
DNA Damage Viewed with Unprecedented Clarity
Amanda Heidt | Aug 15, 2022 | 3 min read
A new tool called PRISM draws on virus-host interactions and a DNA repair pathway to help researchers visualize how cellular stress may contribute to neurodegenerative disease.
An immunoglobulin, also known as an antibody, floating in solution.
Shining a Light on Mass Photometry
The Scientist and Refeyn | Aug 9, 2022 | 3 min read
Mass photometry is an interferometric scattering-based technique offering researchers unprecedented characterization of biomolecular complexes and oligomerization in physiologically-relevant situations.
Photo of Colin Carlson
Colin Carlson Works to Predict and Prevent Viral Spillover
Catherine Offord | Jul 18, 2022 | 3 min read
The Georgetown University biologist studies how climate change contributes to the emergence of new zoonotic threats.
Sleeping mice in chambers with mosquitoes behind them on a mesh
Mosquitoes Drawn to Hosts Infected by Dengue, Zika
Patience Asanga | Jun 30, 2022 | 4 min read
Flavivirus infections alter the skin microbiome of mice to increase the production of a sweet-smelling compound that attracts the viruses’ insect vectors, a study finds.
Exosomes, microvesicles, and apoptotic bodies: The three major types of extracellular vesicle.
Extracellular Vesicles: Applications and Potential
Beckman Coulter Life Sciences | May 13, 2022 | 1 min read
Explore why extracellular vesicles are attractive candidates for new therapeutic approaches.
Explore Solutions for Cell and Gene Therapy Development
Cell and Gene Therapy from the Bench to the Clinic
Bio-Rad Laboratories | Apr 13, 2022 | 1 min read
Researchers use ddPCR to monitor quality at each stage of therapy development.
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