cell signaling

As kinase dysfunction underlies many pathological conditions, scientists require high-quality active kinases for their therapeutic development programs.

The TREM2 receptor may hold the keys to understanding how myeloid cells affect immune responses to neurological disorders and cancer.

Protein characterization can help scientists better understand how molecular events influence health and disease and identify causal factors for disease states.

A new protein sequencing technology paves the way for a better understanding of protein function.

Researchers explore the immune system to further understand cancer and illuminate therapy development.

Children with a multifaceted lung disorder share a receptor deficiency, which has implications for monocyte migration into the lungs.

Mammalian cells outpace bacteriophages in the microbial food chain by devouring phages to fuel their growth.

Cell adhesion may be initiated by small proteins previously viewed as helpers, not main players in attachment.

Gaining a better understanding of the dynamic and reciprocal interactions between cancer cells and the tumor microenvironment is essential for improving patient diagnosis and treatment.

Immune cells and pain neurons form complex partnerships to protect our bodies from pathogens, new research reveals.

Scientists combine microplate readers and cell-based assays for high throughput and reduced variability across a variety of applications.

The Transcreener dAMP Exonuclease Assay reliably locates compounds that antagonize TREX1.

Avoid missing critical cellular behaviors and events through real-time imaging.

Before their own central clocks develop, the brains of fetal rats detect their mother’s metabolic cycle to help regulate the expression of certain genes.

Mass photometry is an interferometric scattering-based technique offering researchers unprecedented characterization of biomolecular complexes and oligomerization in physiologically-relevant situations.

Researchers study sugar modifications to understand health and disease.

An RNA-modifying enzyme passed to daughter cells during budding allows yeast cells to switch between faster- and slower-growing phenotypes.

Karen Abbott and Susan Bellis discuss how to detect and block tumorigenic glycosylation signatures to diagnose and treat cancer.

Using a transgenic fruit fly model, researchers demonstrate how epithelial barriers are maintained in living organisms despite high levels of cell turnover and death.