obesity

Single-cell sequencing unpacked 10 varieties of fat cells, including one that uses an alternative heat-regulating strategy that protects against weight gain.

Popular weight-loss drugs like Ozempic are used to treat obesity and diabetes. Now, researchers found that these drugs also affect rodent brains in other ways. 

Researchers explored the effects of obesity on the lung microenvironment in ferrets, searching for new therapeutic targets to protect vulnerable populations.

Gene mutations in rotund retrievers shed light on the neural regulation of body weight.

Biochemist Sharon Stack hopes to advance the field of ovarian cancer by exploring the tumor and host-related factors that influence its metastatic process. 

Spatial methods reveal immune cell formations in fat during early obesity.

An engineered methylation pattern persisted for four generations of mice, demonstrating transgenerational epigenetic inheritance can occur in mammals.

A high-fat diet induced changes to the animals’ vaginal microbiomes that boosted survival after exposure to the virus.

Epigenetic events, such as methylation, during early brain development in mice occur in genomic regions associated with BMI in humans, according to a new study.

Epigenetic experts discuss how environment and diet leave lasting impressions on the human genome.

Gut microbiome–based solutions hold promise for addressing obesity, but are they overhyped?

The cells signal to the brain how hydrating particular beverages are, but it’s not yet clear whether they play a similar role in humans.

Researchers study obesity by assessing ghrelin levels in biological samples.

Obese mice that exercised while pregnant gave birth to pups that grew up free of the metabolic issues present in the adult young of sedentary obese mothers—possibly by staving off epigenetic changes to a key metabolic gene.

Many major biopharmaceutical companies are developing or acquiring drugs that target the NLRP3 inflammasome, a large intracellular complex that researchers say can spark inflammation and stoke diseases of lifestyle and aging.

Altered gut microbiome composition in obese mice and human patients is linked with severity of disease after bone marrow transplantation, a study found.

Paul Cohen of the Rockefeller University describes his study of thousands of people, finding that the energy-burning tissue is tied to a lower risk of for several diseases, including type 2 diabetes, high blood pressure, and heart disease.

The most common preexisting conditions among the patients were diabetes, obesity, and hypertension.

A video chronicles the course of disease research and prompts questions about where scientists may focus their studies in the future.