protein folding

Durable analytical instruments expedite the study of misfolded proteins linked to neurodegenerative diseases.

Shapeshifting proteins challenge a long-standing maxim in biology.

Textbooks often depict proteins as nicely folded three-dimensional structures, but many proteins are far from it.

By assigning sounds to the dynamic bonds within proteins, scientists gathered new insights on protein folding.

Mutations that loosen rigid proteins turbocharge their nuclear entry.

With deep learning methods revolutionizing life sciences, researchers bet on de novo proteins and cell mapping models to deliver customized precision medicines.

John Jumper and Demis Hassabis received this year’s 2023 Albert Lasker Basic Medical Research Award for their work on the artificial intelligence system AlphaFold, which changed the landscape of protein biology. 

Albumins enable researchers to bind, sequester, and stabilize important molecules across research applications.

From humble yet ingenious beginnings to Nobel recognition, cryogenic electron microscopy (cryo-EM) provides insights into scientific questions that other technologies are unable to answer.

When Gaurav Ghag realized that he had replicated a calculation error in every experiment during four years of his graduate research, he initially thought that his career had unraveled with his protein.  

Machine learning can be harnessed to synthesize artificial light-bearing enzymes that actually work in cells.

Three prizes were awarded to six researchers working across the life sciences on cellular organization, protein structure, and the genetic underpinnings of a chronic sleep disorder.

Researchers study sugar modifications to understand health and disease.

Changes to protein glycosylation play a major role in dictating cancer progression and prognosis, but could they also present biomarkers or therapeutic targets?

An RNA-modifying enzyme passed to daughter cells during budding allows yeast cells to switch between faster- and slower-growing phenotypes.

Conservation of structures and functions between single-celled fungi and human cells allow researchers to probe the brain.

The AlphaFold program from AI firm DeepMind has amassed a huge database of protein structures from humans and model organisms.

An unfolded protein found in human milk shows promise in early clinical trials to treat bladder cancer.

Research by the Stanford University School of Medicine professor revealed how newly formed strings of amino acids fold into complex three-dimensional shapes.