Developmental Biology

While studying the metabolism of the developing chick embryo, Marià Alemany Lamana’s team acted quickly to avert an error.

Studying human embryonic development is complicated for several reasons. Models derived from pluripotent stem cells representing distinct stages offer a path to studying this process.

Culturing pluripotent stem cells to replicate different stages of embryonic development allows researchers to more easily investigate this period.

Leveraging the versatility of stem cells allows researchers to advance science across multiple disciplines.

Scientists have identified a new variant of the cell cycle that could provide insight into how diseases like cancer occur. 

Evgeny Kvon leverages transgenic models and genomic techniques to uncover the ways enhancers control the transcription of genes.

From normal vertebrate development to tumor cell cannibalism, cell-in-cell events occur in many different contexts across the tree of life.

Samantha Brugmann illuminates the cellular and molecular factors that contribute to the formation of craniofacial structures. 

Magdalena Zernicka-Goetz followed the aesthetic allure of the embryo to better understand the start of development.

The mTORC1 signaling pathway senses nutritional information and influences craniofacial development in mice.

A research team showed that, contrary to current models, one early embryonic cell dominates lineages that will become the fetus.

A minimally invasive strategy for creating fetal organoids could facilitate precision medicine in the womb.

Mammary organoids derived from mouse embryonic stem cells could offer clues into mammary gland developmental origins and help researchers study breast cancer.

Jacob Hanna developed a method for replicating embryogenesis outside of the uterus to understand the underlying mechanisms.

p53 is possibly the most important protein for maintaining cellular function. Losing it is synonymous with cancer.

Paul Trainor delves into the genetic and environmental factors that shape the head and face.

During early pregnancy, the placenta remodels the uterine environment to support fetal growth

Recent advances in modeling the human placenta, the least understood organ, may inform placental disorders like preeclampsia.

In the developing zebrafish, a noisy and asynchronous activity jumpstarts the heart’s journey to coordinated beating.