T cells

From manipulating host molecules to concealing their presence in the host’s body, microbes employ a wide range of tactics to dodge immune detection.

Carola Vinuesa’s research has illuminated the genetics of lupus and helped to exonerate a mother falsely accused of murdering her four children. 

A new study finds an unexpected role for hepatocytes in anticancer immunity.

A rare gut cell puzzles researchers by avoiding immune cells.

Oskar Staufer engineers synthetic systems to explore cancer biology.

The FOXO1 transcription factor boosts T cells’ memory and reduces dysfunction.

Timely modulation of a common signaling pathway can preserve influenza memory in lung T cells.

CRISPR-Cas9 editing leads to widespread loss of the targeted chromosome in human T cells, but scientists recently discovered a way to prevent such loss.

By targeting resident memory T cells in the liver, a novel mRNA malaria vaccine prevented infection, even in those with prior exposure.

Immune receptor repertoire profiling is an important analytic tool for disease research in many areas, including cancer, cell and organ transplantation, autoimmunity, and infectious disease. 

An often overlooked property of the tumor environment shapes T cell function and may improve T cell therapies.

Annie Curtis’s research team revealed how circadian rhythm-regulated mitochondrial metabolism drives dendritic cell antigen presentation activity.

Researchers investigated how cancer antigenicity drives unique forms of T cell exhaustion and hypofunctionality.

Male patients who recover from mild COVID-19 have baseline immune states primed to mount stronger responses to future challenges than female patients.

New research may make immunotherapy possible for hard-to-treat brain tumors.

An automated counterflow centrifugation–based technology outperforms manual peripheral blood mononuclear cell (PBMC) isolation.

Susan Thomas discusses how her team engineered a microfluidic device to screen for T cells with improved homing capability to tumor cells. 

A well-established monitoring system can ensure a constant and stable environment for CAR T cell production. 

Males recovered from mild COVID-19 have baseline immune states primed to mount stronger responses to future challenges.