A pink and yellow protein held together by a gray circle pulls a piece of blue DNA into a loop.

Combining Bacterial Systems Offers a New Approach to Gene Regulation

Researchers turned programmable proteins into a novel genetic tool, potentially enabling tighter control of gene expression.

Combining Bacterial Systems Offers a New Approach to Gene Regulation

Researchers turned programmable proteins into a novel genetic tool, potentially enabling tighter control of gene expression.

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gene repressors

The Regulation of the lac Operon

Shelby Bradford, PhD | Dec 13, 2024 | 4 min read

Gene expression of lactose-digesting genes is controlled by the lac operon that accounts for varying amounts of lactose or glucose in the cell.

3D illustration of RNA polymerase (blue, middle) transcribing a segment of DNA (purple) into an RNA chain (red, extending to top).

The lac Operon: A Lesson in Simple Gene Regulation

Shelby Bradford, PhD | Dec 13, 2024 | 10+ min read

The discovery of an inducible switch in Escherichia coli that controlled lactose metabolism offered the first clues into gene expression.

(Re)Programming Director

Karen Hopkin | Oct 1, 2012 | 9 min read

Unwilling to accept the finality of terminal differentiation, Helen Blau has honed techniques that showcase the flexibility of cells to adopt different identities.